Involvement of AP-1 in Interleukin-1 –Stimulated MMP-3 Expression in Human Trabecular Meshwork Cells
نویسندگان
چکیده
PURPOSE. Stromelysin-1 (MMP-3) degrades extracellular matrix and increases aqueous outflow. In the trabecular meshwork (TM), interleukin (IL)-1 is a potent inducer of MMP-3 expression. In different cells, IL-1 activates different signaling pathways, such as nuclear factor (NF)B–mediated protein expression, the phospholipase A2 (PLA2)–activated arachidonate cascade, and activator protein (AP)-1–associated transcription. In the present study, pharmacological tools were used to delineate the signaling mechanism involved in the effect of IL-1 on MMP-3 production in human TM cells compared with other ocular cells.
منابع مشابه
Involvement of AP-1 in interleukin-1alpha-stimulated MMP-3 expression in human trabecular meshwork cells.
PURPOSE Stromelysin-1 (MMP-3) degrades extracellular matrix and increases aqueous outflow. In the trabecular meshwork (TM), interleukin (IL)-1alpha is a potent inducer of MMP-3 expression. In different cells, IL-1alpha activates different signaling pathways, such as nuclear factor (NF)-kappaB-mediated protein expression, the phospholipase A(2) (PLA(2))-activated arachidonate cascade, and activa...
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